This research examines the connection between Green Human Resource Management (GHRM) and Sustainable Performance (SP) in Spanish wineries, emphasizing the mediating roles of Employee Wellbeing (EW) and Work Engagement (WE). This study is pertinent, given the growing focus on sustainability as a core business strategy. To refine the precision of the examined cause-effect relationships, variables such as the age and size of the winery and membership in a Protected Designation of Origin (PDO) are incorporated as controls. Utilizing a conceptual model informed by prior studies, this study employs structural equation modeling (PLS-SEM) to analyze data from 196 wineries collected from September 2022 to January 2023. The findings highlight a positive and significant link between GHRM practices and the SP of these wineries, with EW and WE serving as partial mediators. The significance of this study lies in its contribution to the understanding of GHRM’s benefits in enhancing SP, particularly in the Spanish wine industry, a context not extensively explored in previous research. To the best of our knowledge, this study is the first to investigate the mediating effects of EW and WE on the GHRM-SP relationship in this sector, marking a notable advancement in this field.